I never got along with any of the multi-effect, patch oriented things... or the Guitar synth that I owned for a while... added complications, tweaking, messing... and was never 100% reliable or bullet proof come gig time.
Even when I was blown away by Brooks and Dunn's guitar player using a pair of Kempers and spent time talking to their guitar tech, I wasn't sure if I would get along with it....
.... but once I knew I would have THIS amp in slot one.... for clean, THIS amp in slot two for crunch... and then some different lead choices... and the appropriate effects queued up so when I go to clean it has reverb but chorus and compression available up top... but then my lead tone would already have the drive and delays enabled, but I could tap tempo them or switch it off and throw a flanger in.... then it was finally simple and usable.
When I use my Kemper I don't feel like it's 50 amps and 100 effects... I feel like the first button takes me to a Matchless with options for a crisp Delay or crystal Delay, Chorus, Compression, and Boost... or I switch to an Orange with a booster, analogue delay, and choice of Flange Phase, and then a HotRod Marshall with delay and boost.
I have a couple other patches lined up for individual songs, but realistically I will use one "Amp" and effect for an entire song and toggle the effects off/on for parts... or some songs will jump between two different rigs, but I'm not using a ton of effects or 6 different patches per song.