One of the first things I had to do was go into the configuration and "flip" the fingerboard.
I appreciate that they set it up so when you're looking at the neck on the screen that they set it up as if you're looking THROUGH the neck, but when I would look at a chord on the screen it wouldn't register as to what chord they were trying to make.
I spent a little time browsing the mini games, played through "Every Breath you Take" a few times, and messed about in the "Studio".
It's kinda weird at first where you're only playing every 5th or 6th note but after a while I just started playing what I was hearing on the track and more notes started popping up for me to play for points. It doesn't seem to penalize you for playing extra notes or noodling as long as it's in key.
The Studio function was pretty impressive. I set it to drums, piano, and slap bass... then set it to Blues in B with changes. It shows you the key that the next chord change is going to be in and as you play more aggressively the "band" follows.... but if you start picking softer, the music relaxes into your groove.